8-Chloroadenosine
8-Chloroadenosine (NSC-354258) is a nucleoside analog metabolized to 8-Chloro-ATP, incorporating into RNA to inhibit synthesis and deplete cellular ATP. It acts as an AMPK agonist, inhibits the mTOR pathway, and demonstrates cytotoxic activity in vitro against various leukemia, myeloma, and solid tumor cell lines, inducing cell cycle arrest.
Product Specifications
CAS Number
34408-14-5
Product Name Alternative
NSC354258, NSC-354258, NSC 354258, 5'-AMP-activated protein kinase, 8Chloroadenosine, 8-Chloroadenosine, 8-Cl-Ado, 8 Chloroadenosine
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
98.75% (May vary between batches)
Solubility
DMSO:65 mg/mL (215.45 mM)
Smiles
ClC=1N (C=2C (N1) =C (N) N=CN2) [C@@H]3O[C@H] (CO) [C@@H] (O) [C@H]3O
Molecular Formula
C10H12ClN5O4
Molecular Weight
301.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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