AZD-3463
AZD-3463 is a potent, orally active small molecule inhibitor of ALK (Ki=0.75 nM) and IGF1R. It is utilized in preclinical research to investigate targeted therapies, particularly in oncology models studying ALK- and IGF1R-driven cancers in both cellular and animal studies.
Product Specifications
CAS Number
1356962-20-3
Product Name Alternative
Cluster of differentiation 246, CD246, crizotinib, Autophagy, AZD3463, AZD-3463, AZD 3463, Apoptosis, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, ALK/IGF1R inhibitor, ALK tyrosine kinase receptor, ALK, inhibit, kinase, neuroblastoma, IGF1R, IGF-1R, Inhibitor, PI3K/AKT/mTOR. pathway, receptor, resistance, tyrosine
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:23 mg/mL (51.23 mM)
Smiles
COc1cc (ccc1Nc1ncc (Cl) c (n1) -c1c[nH]c2ccccc12) N1CCC (N) CC1
Molecular Formula
C24H25ClN6O
Molecular Weight
448.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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