GSK-5959
GSK-5959 is a potent, selective, and cell-permeable small molecule inhibitor of the BRPF1 bromodomain, exhibiting an IC50 of approximately 80 nM. It demonstrates over 100-fold selectivity against 35 other bromodomains, including BRPF2/3 and BET family members. This inhibitor is a valuable chemical probe for investigating BRPF1 function in epigenetic regulation and related disease models in both cellular and in vivo contexts.
Product Specifications
CAS Number
901245-65-6
Product Name Alternative
GSK 5959, GSK5959, GSK-5959, epigenetics, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit, Inhibitor, bromodomain, BRPF2, BRPF3, BRPF1, BRD1
Field of Research
Epigenetics & Chromatin
Purity
98.35% (May vary between batches)
Solubility
DMSO:10 mg/mL (25.35 mM)
Smiles
COc1ccccc1C (=O) Nc1cc2n (C) c (=O) n (C) c2cc1N1CCCCC1
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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