NVP-BGJ398
Infigratinib (BGJ398) is a potent and orally available pan-FGFR inhibitor with IC50 values of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively. It demonstrates high selectivity over FGFR4 and VEGFR2. This inhibitor is widely used in preclinical research to study FGFR-driven cancers in both cellular assays and animal models.
Product Specifications
CAS Number
872511-34-7
Product Name Alternative
Infigratinib
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
>98%
Bioactivity
Pan-specific FGFR inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 5 mg/ml)
Smiles
CCN1CCN (CC1) c1ccc (Nc2cc (ncn2) N (C) C (=O) Nc2c (Cl) c (OC) cc (OC) c2Cl) cc1
Molecular Formula
C26H31Cl2N7O3
Molecular Weight
560.48
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3- (2,6-Dichloro-3,5-dimethoxyphenyl) -1- (6-{[4- (4-ethyl-1-piperazinyl) phenyl]amino}-4-pyrimidinyl) -1-methylurea
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