LDN-212854
LDN-212854 is a selective BMP pathway inhibitor with high potency against ALK2 (IC50=1.3 nM) and distinct activity profiles towards ALK1 and ALK3. It is a valuable research tool for studying BMP signaling in vitro and has been used in vivo to investigate bone formation, heterotopic ossification, and iron metabolism pathways.
Product Specifications
CAS Number
1432597-26-6
Product Name Alternative
TGF-β/Smad, TGF-β Receptor, TGFβ, TGFbeta/Smad, TGFb, TGF-b/Smad, TGFbeta, TGF-beta, Transforming growth factor beta receptors, Smad, Huh7, FOP model, EpCAM, heterotopic ossification, HCC, LDN 212854, LDN212854, LDN-212854, MT cell, inhibit, Inhibitor, ALK2, ALK1, ALK3, ALK4, ALK5, BMP, BMP Inhibitor III, BMP9-ID1 signaling, BMPR2 cell
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:10.42 mg/mL (25.63 mM)
Smiles
C1CN (CCN1) c1ccc (cc1) -c1cnc2c (cnn2c1) -c1cccc2ncccc12
Molecular Formula
C25H22N6
Molecular Weight
406.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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