Dabrafenib (GSK2118436)
Dabrafenib is a potent and ATP-competitive inhibitor of B-RafV600E and C-Raf kinases. It demonstrates significant antitumor efficacy in preclinical models of B-Raf-mutant melanoma, supporting its use in both in vitro biochemical assays and in vivo xenograft studies for cancer research.
Product Specifications
CAS Number
1195765-45-7
Product Name Alternative
GSK2118436
Field of Research
Cell Biology
Purity
>98%
Bioactivity
B-Raf mutant inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming) .
Smiles
CC (C) (C) c1nc (c (s1) -c1ccnc (N) n1) -c1cccc (NS (=O) (=O) c2c (F) cccc2F) c1F
Molecular Formula
C23H20F3N5O2S
Molecular Weight
519.56
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[3-[5- (2-amino-4-pyrimidinyl) -2- (1,1-dimethylethyl) -4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
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