AM251
AM251 is a potent and selective cannabinoid receptor 1 (CB1) antagonist (IC50: 8 nM; Ki: 7.49 nM) with a 306-fold selectivity over CB2. It also acts as an effective GPR55 agonist (EC50: 39 nM) . This compound is widely used in vitro and in vivo to investigate the endocannabinoid system in metabolic, neurological, and pain research.
Product Specifications
CAS Number
183232-66-8
Product Name Alternative
AM 251, AM251, AM-251, Cannabinoid Receptor, CannabinoidReceptor, CB1, CB, inhibit, Inhibitor, GPR55
Field of Research
Neuroscience
Purity
>98%
Bioactivity
Cannabinoid CB1 antagonist
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 13 mg/ml)
Smiles
CC1=C (N (N=C1C (NN2CCCCC2) =O) C3=C (Cl) C=C (Cl) C=C3) C4=CC=C (I) C=C4
Molecular Formula
C22H21Cl2IN4O
Molecular Weight
555.24
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N- (Piperidin-1-yl) -5- (4-iodophenyl) -1- (2,4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide
Available Sizes
Frequently Asked Questions
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