1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
Selected Variant
HY-W583868-01
Size: 5 mg
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines[1][2].
Product Specifications
CAS Number
26662-94-2
Product Name Alternative
1,2-POPE; 16:0-18:1 PE
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H331, H336, H351, H372, H412
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/1-palmitoyl-2-oleoyl-sn-glycero-3-pe.html
Purity
99.46
Solubility
Methanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O
Molecular Formula
C39H76NO8P
Molecular Weight
718.00
Precautions
H302, H315, H319, H331, H336, H351, H372, H412
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Price
Frequently Asked Questions
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