1-Palmitoyl-2-oleoyl-sn-glycero-3-PE

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines[1][2].

Product Specifications

CAS Number

[26662-94-2]

Product Name Alternative

1,2-POPE; 16:0-18:1 PE

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H331, H336, H351, H372, H412

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-palmitoyl-2-oleoyl-sn-glycero-3-pe.html

Purity

99.46

Solubility

Methanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C39H76NO8P

Molecular Weight

718.00

Precautions

H302, H315, H319, H331, H336, H351, H372, H412

References & Citations

[1]Álvarez-Benedicto E, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA) . Biomater Sci. 2022 Jan 18;10 (2) :549-559.|[2]Guo L, et al. A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines. Anal Biochem. 2010 Oct 15;405 (2) :236-45.