Anacetrapib
Anacetrapib (MK-0859) is a potent and reversible inhibitor of CETP, with IC50 values of 7.9 nM for rhCETP and 11.8 nM for the C13S mutant. It blocks cholesteryl ester transfer from HDL to LDL/VLDL, elevating HDL-cholesterol and lowering LDL-cholesterol in serum. This mechanism has been investigated in both in vitro assays and in vivo preclinical models of dyslipidemia.
Product Specifications
CAS Number
875446-37-0
Product Name Alternative
CETP, Cholesteryl ester transfer protein, Anacetrapib, MK 0859, MK0859, MK-0859, Inhibitor, inhibit, Mutant CETP (C13S), rhCETP
Field of Research
Metabolism Research
Purity
97.09% (May vary between batches)
Solubility
DMSO:50 mg/mL (78.43 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+90% Corn Oil:2.5 mg/mL (3.92 mM) ; Ethanol:57 mg/mL (89.41 mM)
Smiles
COc1cc (F) c (cc1-c1ccc (cc1CN1[C@@H] (C) [C@H] (OC1=O) c1cc (cc (c1) C (F) (F) F) C (F) (F) F) C (F) (F) F) C (C) C
Molecular Formula
C30H25F10NO3
Molecular Weight
637.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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