Filgotinib

Filgotinib (GLPG0634) is a potent and selective Janus kinase 1 (JAK1) inhibitor, exhibiting IC50 values of 10 nM, 28 nM, 810 nM, and 116 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This small molecule is a valuable research tool for investigating JAK-STAT signaling in inflammatory and autoimmune disease models, both in vitro and in vivo.