Filgotinib
Filgotinib (GLPG0634) is a potent and selective Janus kinase 1 (JAK1) inhibitor, exhibiting IC50 values of 10 nM, 28 nM, 810 nM, and 116 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This small molecule is a valuable research tool for investigating JAK-STAT signaling in inflammatory and autoimmune disease models, both in vitro and in vivo.
Product Specifications
CAS Number
1206161-97-8
Product Name Alternative
GLPG0634; GS-6034
Field of Research
Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
JAK1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (15 mg/ml, warm)
Smiles
O=C (Nc1nc2cccc (-c3ccc (CN4CCS (=O) (=O) CC4) cc3) n2n1) C1CC1
Molecular Formula
C21H23N5O3S
Molecular Weight
425.5
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[5-[4-[ (1,1-dioxido-4-thiomorpholinyl) methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide
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