SEW2871
SEW 2871 is a potent and selective oral S1P1 receptor agonist (EC50=13.8 nM) that induces lymphocyte reduction and receptor internalization. It is utilized in research models for inflammation, liver fibrosis, Alzheimer's disease, and diabetes, where it modulates ERK, Akt, and Rac signaling pathways.
Product Specifications
CAS Number
256414-75-2
Product Name Alternative
Colitis, Crohn's disease, diabetes, Akt, Alzheimer's disease, ERK, Extracellular signal regulated kinases, Inhibitor, inhibit, ischaemia-reperfusion injury, LX-2 cells, LPLReceptor, LPL, LPL Receptor, liver fibrosis, Lysophospholipid Receptor, orally active, S1P1, S1P Receptor, S1PReceptor, SEW?2871, SEW2871, SEW-2871, SEW2871, SEW 2871, PKB, Protein kinase B
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.27 mM) ; DMSO:8.8 mg/mL (19.98 mM)
Smiles
FC (F) (F) c1sc (cc1-c1ccccc1) -c1nc (no1) -c1cccc (c1) C (F) (F) F
Molecular Formula
C20H10F6N2OS
Molecular Weight
440.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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