MS37452
MS37452 is a small molecule that competitively inhibits the CBX7 chromodomain from binding to the H3K27me3 histone mark with a Ki of 43 μM. This inhibitor is a valuable chemical probe for studying Polycomb repressive complex function in epigenetics, cancer research, and stem cell biology, applicable in both in vitro and cellular assays.
Product Specifications
CAS Number
423748-02-1
Product Name Alternative
P16/CDKN2A, transcription, CBX7, CBX7 chromodomain, derepress, anticancer, inhibit, Inhibitor, MS 37452, MS37452, MS-37452, INK4A/ARF, Histone Methyltransferase, HistoneMethyltransferase, H3K27me3
Field of Research
Epigenetics & Chromatin
Purity
99.39% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM) ; DMSO:60 mg/mL (150.58 mM)
Smiles
COc1cccc (C (=O) N2CCN (CC2) C (=O) COc2cccc (C) c2) c1OC
Molecular Formula
C22H26N2O5
Molecular Weight
398.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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