MS37452
MS37452 is a small molecule that competitively inhibits the CBX7 chromodomain from binding to the H3K27me3 histone mark with a Ki of 43 μM. This inhibitor is a valuable chemical probe for studying Polycomb repressive complex function in epigenetics, cancer research, and stem cell biology, applicable in both in vitro and cellular assays.
Product Specifications
CAS Number
423748-02-1
Product Name Alternative
P16/CDKN2A, transcription, CBX7, CBX7 chromodomain, derepress, anticancer, inhibit, Inhibitor, MS 37452, MS37452, MS-37452, INK4A/ARF, Histone Methyltransferase, HistoneMethyltransferase, H3K27me3
Field of Research
Epigenetics & Chromatin
Purity
99.39% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM) ; DMSO:60 mg/mL (150.58 mM)
Smiles
COc1cccc (C (=O) N2CCN (CC2) C (=O) COc2cccc (C) c2) c1OC
Molecular Formula
C22H26N2O5
Molecular Weight
398.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
125195-ML750 100 µL
COLEC10 (Collectin-10, Collectin Liver Protein 1, CL-L1, Collectin-34, CL-34, CLL1, UNQ366/PRO702) (MaxLight 750) discontinued
Sign In for Pricing
View Details MBS6335878-01 0.1 mL
PON1, ID (PON1, PON, Serum paraoxonase/arylesterase 1, Aromatic esterase 1, K-45, Serum aryldialkylphosphatase 1) (MaxLight 405)
Sign In for Pricing
View Details MBS6335878-02 5x 0.1 mL
PON1, ID (PON1, PON, Serum paraoxonase/arylesterase 1, Aromatic esterase 1, K-45, Serum aryldialkylphosphatase 1) (MaxLight 405)
Sign In for Pricing
View Details C9095-45K 200 µL
CYP4F12, CT (Cytochrome P450 4F12, CYPIVF12, UNQ568/PRO1129)
Sign In for Pricing
View Details