Sephin1
Sephin1 (IFB-088) is a selective small molecule inhibitor of GADD34 (PPP1R15A) . By blocking this stress-induced regulatory subunit, it prolongs eIF2α phosphorylation, thereby modulating the integrated stress response. This action has shown protective effects in preclinical models of protein misfolding diseases, such as neurodegenerative disorders.
Product Specifications
CAS Number
13098-73-2
Product Name Alternative
(E/Z) -Icerguastat, (E/Z) -Sephin1, IFB 088, IFB088, IFB-088, NSC65390, NSC-65390, NSC 65390, inhibit, Inhibitor, Phosphatase, phosphatase PPP1R15A, PPP1R15A, PPP1R15B, Sephin-1, Sephin1, protein misfolding diseases
Field of Research
Metabolism Research
Purity
99.24% (May vary between batches)
Solubility
DMSO:7 mg/mL (35.6 mM) ; H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.09 mM)
Smiles
C (=NNC (=N) N) C1=C (Cl) C=CC=C1
Molecular Formula
C8H9ClN4
Molecular Weight
196.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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