JGB1741
JGB1741 is a potent and selective SIRT1 inhibitor (IC50=15 μM) that induces p53-mediated apoptosis in breast cancer cells by modulating the Bax/Bcl-2 ratio and increasing acetylated p53 levels. Its mechanism, involving cytochrome c release and PARP cleavage, supports its use in vitro for studying oncogenic cell survival pathways.
Product Specifications
CAS Number
1256375-38-8
Product Name Alternative
SIRT1, ILS-JGB 1741, ILS-JGB1741, ILS-JGB-1741, JGB-1741, JGB 1741, JGB1741
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
97.24% (May vary between batches)
Solubility
DMSO:4.41 mg/mL (10.01 mM)
Smiles
Oc1ccc2ccccc2c1\C=N\c1sc2CCCCc2c1C (=O) NCc1ccccc1
Molecular Formula
C27H24N2O2S
Molecular Weight
440.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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