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Org 25543 hydrochloride

Org 25543 hydrochloride is a highly selective and potent inhibitor of the glycine transporter type 2 (GlyT2), exhibiting an IC50 of 16 nM against hGlyT2. It shows no significant activity at GlyT1 or 56 other common targets at concentrations up to 100 μM. This inhibitor is a valuable research tool for investigating glycinergic neurotransmission in models of neuropathic pain and hyperekplexia.

Product Specifications

CAS Number

495076-64-7

Product Name Alternative

Org 25543 Hydrochloride, Org 25543 hydrochloride, GlyT2

Field of Research

Neuroscience

Purity

99.26% (May vary between batches)

Solubility

H2O:8 mg/mL (17.82 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.23 mM) ; DMSO:60 mg/mL (133.64 mM)

Smiles

Cl.COc1cc (cc (OC) c1OCc1ccccc1) C (=O) NCC1 (CCCC1) N (C) C

Molecular Formula

C24H33ClN2O4

Molecular Weight

448.983

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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