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2-Methoxyestradiol

2-Methoxyestradiol (2-ME2) is an orally active endogenous metabolite with potent anti-tumor properties. It functions as an anti-angiogenic agent by disrupting endothelial cell function and exerts direct antiproliferative effects on cancer cells through tubulin binding and induction of apoptosis. This small molecule is widely used in oncology research for both in vitro mechanistic studies and in vivo xenograft models.

Product Specifications

CAS Number

362-07-2

Product Name Alternative

NSC 659853, inhibit, Microtubule/Tubulin, Microtubule depolymerization, Microtubule Associated, MicrotubuleAssociated, NSC659853, NSC-659853, Inhibitor, HIF-2α, HIF-1α, EndogenousMetabolite, Endogenous Metabolite, Autophagy, Apoptosis, 2 Methoxyestradiol, 2Methoxyestradiol, 2-Methoxyestradiol, 2-ME2, 2-MeOE2, ReactiveOxygenSpecies, Reactive Oxygen Species

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction

Purity

98.00% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM) ; DMSO:45 mg/mL (148.8 mM)

Smiles

[H][C@@]12CC[C@H] (O) [C@@]1 (C) CC[C@]1 ([H]) c3cc (OC) c (O) cc3CC[C@@]21[H]

Molecular Formula

C19H26O3

Molecular Weight

302.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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