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Ensartinib hydrochloride

Ensartinib hydrochloride (X-396 dihydrochloride) is a next-generation, potent ALK inhibitor effective against wild-type ALK and multiple crizotinib-resistant mutants, including G1202R and L1196M, with IC50 values below 4 nM. It demonstrates significant activity against central nervous system metastases and is utilized in preclinical oncology research for both in vitro and in vivo studies of ALK-driven cancers.

Product Specifications

CAS Number

2137030-98-7

Product Name Alternative

Cluster of differentiation 246, CD246, cMet, c-Met, cMet/HGFR, c-Met/HGFR, ALK tyrosine kinase receptor, ALK variants, ALK, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, GOPC-ROS1, Ensartinib, Ensartinib dihydrochloride, Ensartinib Dihydrochloride, Ensartinib Hydrochloride, Ensartinib hydrochloride, HGFR, inhibit, Inhibitor, X 396, X 396 Dihydrochloride, X-396 Dihydrochloride, X396, X-396, X396 Dihydrochloride, X-396 dihydrochloride, TPM3-TRKA, Trk receptor, TRKC, Trkreceptor

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.73% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.15 mM) ; DMSO:33 mg/mL (52.02 mM)

Smiles

Cl.Cl.C[C@@H] (Oc1cc (nnc1N) C (=O) Nc1ccc (cc1) C (=O) N1C[C@H] (C) N[C@H] (C) C1) c1c (Cl) ccc (F) c1Cl

Molecular Formula

C26H29Cl4FN6O3

Molecular Weight

634.36

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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