Ensartinib hydrochloride
Ensartinib hydrochloride (X-396 dihydrochloride) is a next-generation, potent ALK inhibitor effective against wild-type ALK and multiple crizotinib-resistant mutants, including G1202R and L1196M, with IC50 values below 4 nM. It demonstrates significant activity against central nervous system metastases and is utilized in preclinical oncology research for both in vitro and in vivo studies of ALK-driven cancers.
Product Specifications
CAS Number
2137030-98-7
Product Name Alternative
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.73% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.15 mM) ; DMSO:33 mg/mL (52.02 mM)
Smiles
Cl.Cl.C[C@@H] (Oc1cc (nnc1N) C (=O) Nc1ccc (cc1) C (=O) N1C[C@H] (C) N[C@H] (C) C1) c1c (Cl) ccc (F) c1Cl
Molecular Formula
C26H29Cl4FN6O3
Molecular Weight
634.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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