GNE-490
GNE-490 is a potent and selective pan-PI3K inhibitor, exhibiting low nanomolar IC50 values against PI3Kα, β, δ, and γ isoforms while showing over 200-fold selectivity over mTOR. This profile makes it a valuable chemical probe for investigating PI3K pathway biology in cancer and immunological research, both in vitro and in vivo.
Product Specifications
CAS Number
1033739-92-2
Product Name Alternative
GNE 490, GNE490, GNE-490, Inhibitor, MCF7.1, Mammalian target of Rapamycin, inhibit, mTOR, breast cancer, PI3K, PI3Kβ, PI3Kγ, PI3Kα, PI3Kδ, Phosphoinositide 3-kinase
Field of Research
Signal Transduction
Purity
96.74% (May vary between batches)
Solubility
DMSO:50 mg/mL (129.38 mM)
Smiles
Cc1nc (N) ncc1-c1nc (N2CCOCC2) c2sc (cc2n1) C (C) (C) O
Molecular Formula
C18H22N6O2S
Molecular Weight
386.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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