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GNE-490

GNE-490 is a potent and selective pan-PI3K inhibitor, exhibiting low nanomolar IC50 values against PI3Kα, β, δ, and γ isoforms while showing over 200-fold selectivity over mTOR. This profile makes it a valuable chemical probe for investigating PI3K pathway biology in cancer and immunological research, both in vitro and in vivo.

Product Specifications

CAS Number

1033739-92-2

Product Name Alternative

GNE 490, GNE490, GNE-490, Inhibitor, MCF7.1, Mammalian target of Rapamycin, inhibit, mTOR, breast cancer, PI3K, PI3Kβ, PI3Kγ, PI3Kα, PI3Kδ, Phosphoinositide 3-kinase

Field of Research

Signal Transduction

Purity

96.74% (May vary between batches)

Solubility

DMSO:50 mg/mL (129.38 mM)

Smiles

Cc1nc (N) ncc1-c1nc (N2CCOCC2) c2sc (cc2n1) C (C) (C) O

Molecular Formula

C18H22N6O2S

Molecular Weight

386.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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