NVP-BEZ235
Dactolisib (BEZ235) is a potent, orally active dual inhibitor of PI3K and mTOR kinase, with low nanomolar IC50 values against all PI3K isoforms and mTOR. It is widely used in preclinical research to investigate the PI3K/AKT/mTOR signaling pathway in cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
915019-65-7
Product Name Alternative
Field of Research
Cardiovascular Research, Cell Biology
Purity
>98%
Bioactivity
PI 3-K and mTOR inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75°C) .
Smiles
O=C1N (C=2C=3C (N=CC2N1C) =CC=C (C3) C4=CC5=C (N=C4) C=CC=C5) C6=CC=C (C (C#N) (C) C) C=C6
Molecular Formula
C30H23N5O
Molecular Weight
469.55
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Methyl-2-{4-[3-methyl-2-oxo-8- (quinolin-3-yl) -2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
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