ICG-001
ICG001 is a selective CBP/β-catenin antagonist that inhibits Wnt-responsive transcription with an IC50 of 3 μM. It is a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has been utilized in both cellular and animal models of tumorigenesis.
Product Specifications
CAS Number
847591-62-2
Product Name Alternative
Epigenetic Reader Domain, EpigeneticReaderDomain, ICG001, ICG-001, ICG 001, CBP, beta-catenin, betacatenin, 780757-88-2, 847591-62-2, bcatenin, PRI 724, PRI724, PRI-724, PRI-724 isomer, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, Wnt, βcatenin
Field of Research
Cell Biology, Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Wnt/β-catenin inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml)
Smiles
Oc1ccc (C[C@@H]2N3[C@H] (CN (Cc4cccc5ccccc45) C2=O) N (CCC3=O) C (=O) NCc2ccccc2) cc1
Molecular Formula
C33H32N4O4
Molecular Weight
548.63
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(6S,9aS) -hexahydro-6-[ (4-hydroxyphenyl) methyl]-8- (1-naphthalenylmethyl) -4,7-dioxo-N- (phenylmethyl) -2H-pyrazino[1,2-a]pyrimidine-1 (6H) -carboxamide
Available Sizes
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