PF-6274484
PF-6274484 is a potent, irreversible covalent EGFR kinase inhibitor with a Ki of 0.14 nM. It effectively blocks autophosphorylation of wild-type EGFR and the EGFRL858R/T790M mutant in cellular assays, with IC50 values of 5.8 nM and 6.6 nM, respectively. This inhibitor is a valuable tool for in vitro research in non-small cell lung cancer and resistance mechanism studies.
Product Specifications
CAS Number
1035638-91-5
Product Name Alternative
Cysteine, autophosphorylation, kinase, inhibit, HER1, Inhibitor, Epidermal growth factor receptor, ErbB-1, EGFR, signaling, oxidation, PF-6274484, PF6274484, PF 6274484, protein
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.71% (May vary between batches)
Solubility
DMSO:65 mg/mL (174.37 mM)
Smiles
COc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1NC (=O) C=C
Molecular Formula
C18H14ClFN4O2
Molecular Weight
372.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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