What is the catalog number for PF-6274484?

The catalog number for PF-6274484 is orb1305952.

What sizes are available for PF-6274484?

PF-6274484 is available in the following size(s): 2 mg, 5 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg, 500 mg.

How many pack sizes does PF-6274484 come in?

PF-6274484 is available in 8 different pack sizes.

Is PF-6274484 in stock?

PF-6274484 is currently made to order / not held in immediate stock. Contact us for lead time.

PF-6274484

PF-6274484 is a potent, irreversible covalent EGFR kinase inhibitor with a Ki of 0.14 nM. It effectively blocks autophosphorylation of wild-type EGFR and the EGFRL858R/T790M mutant in cellular assays, with IC50 values of 5.8 nM and 6.6 nM, respectively. This inhibitor is a valuable tool for in vitro research in non-small cell lung cancer and resistance mechanism studies.

Product Specifications

CAS Number

1035638-91-5

Product Name Alternative

Cysteine, autophosphorylation, kinase, inhibit, HER1, Inhibitor, Epidermal growth factor receptor, ErbB-1, EGFR, signaling, oxidation, PF-6274484, PF6274484, PF 6274484, protein