Alisertib (MLN8237)
Alisertib (MLN8237) is a potent and selective oral Aurora A kinase inhibitor (IC50=1.2 nM) . It exhibits antitumor activity by inducing cell cycle arrest, apoptosis, and autophagy, as demonstrated in both in vitro cellular assays and in vivo xenograft models across various cancer research fields.
Product Specifications
CAS Number
1028486-01-2
Product Name Alternative
MLN8237
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Aurora A inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 5 mg/ml)
Smiles
COc1cc (Nc2ncc3CN=C (c4cc (Cl) ccc4-c3n2) c2c (F) cccc2OC) ccc1C (O) =O
Molecular Formula
C27H20ClFN4O4
Molecular Weight
518.9
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-{[9-chloro-7- (2-fluoro-6-methoxyphenyl) -5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
Available Sizes
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