RO495
RO495 (CS-2667) is a highly potent and selective TYK2 inhibitor, demonstrating an IC50 of 1.5 nM in cellular assays. This small molecule is a valuable research tool for investigating TYK2-dependent signaling in immunological and inflammatory diseases, with utility in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
1258296-60-4
Product Name Alternative
CS2667, CS-2667, CS 2667, Inhibitor, JAK, inhibit, Janus kinase, RO495, RO-495, RO 495, Tyrosine Kinases, TyrosineKinases, TYK2
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.94% (May vary between batches)
Solubility
DMSO:9 mg/mL (23.12 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM)
Smiles
Cc1cc (Nc2cc (NC (=O) c3c (Cl) cccc3Cl) ccn2) nc (N) n1
Molecular Formula
C17H14Cl2N6O
Molecular Weight
389.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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