Serdemetan
Serdemetan (JNJ-26854165) is an orally active small molecule antagonist of HDM2, which disrupts the p53-HDM2 interaction to reactivate tumor suppression. It has demonstrated antineoplastic activity in preclinical in vitro and in vivo cancer models, supporting its investigation in oncology research.
Product Specifications
CAS Number
881202-45-5
Product Name Alternative
E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, Apoptosis, JNJ26854165, JNJ-26854165, JNJ 26854165, inhibit, p53, Inhibitor, HDM2, Mdm2, MDM-2/p53, E3 ligating enzyme, E3Enzyme, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase, Serdemetan
Field of Research
Cell Biology, Protein Biochemistry
Purity
97.13% (May vary between batches)
Solubility
DMSO:50 mg/mL (152.25 mM) ; Ethanol:2 mg/mL (6.09 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.09 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
C (Cc1c[nH]c2ccccc12) Nc1ccc (Nc2ccncc2) cc1
Molecular Formula
C21H20N4
Molecular Weight
328.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RC211091L4V 200 µL
INPP5F (NM_014937) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details MBS1394800-01 0.02 mg (E-Coli)
Recombinant Anabaena variabilis Isopentenyl-diphosphate delta-isomerase (fni)
Sign In for Pricing
View Details MBS1394800-02 0.02 mg (Yeast)
Recombinant Anabaena variabilis Isopentenyl-diphosphate delta-isomerase (fni)
Sign In for Pricing
View Details MBS1394800-03 0.1 mg (E-Coli)
Recombinant Anabaena variabilis Isopentenyl-diphosphate delta-isomerase (fni)
Sign In for Pricing
View Details