Takeda-6d
Takeda-6d is a potent DFG-out inhibitor targeting RAF and VEGFR2 kinases, exhibiting IC50 values of 7.0 nM and 2.2 nM, respectively. This small molecule is a valuable research tool for investigating oncogenic signaling and angiogenesis in both cellular and animal models of cancer.
Product Specifications
CAS Number
1125632-93-0
Product Name Alternative
Antiangiogenesis, antitumor, inhibit, orally active, Inhibitor, HUVEC cells, PERK, Raf, Raf kinases, PKR-like endoplasmic reticulum kinase, Protein kinase R-like endoplasmic reticulum kinase, Takeda 6d, Takeda6d, Takeda-6D, Takeda-6d, VEGFR, VEGFR2, Vascular endothelial growth factor receptor
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.27% (May vary between batches)
Solubility
DMSO:65 mg/mL (118.62 mM)
Smiles
Fc1ccc (Oc2ccc3nc (NC (=O) C4CC4) sc3n2) cc1NC (=O) c1cccc (c1Cl) C1 (CC1) C#N
Molecular Formula
C27H19ClFN5O3S
Molecular Weight
547.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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