YKL-5-124
YKL-5-124 is a covalent, highly selective CDK7 inhibitor with an IC50 of 9.7 nM against the CDK7/Mat1/CycH complex, demonstrating over 130-fold selectivity versus CDK2 and CDK9. It is a valuable chemical probe for studying transcriptional regulation and cell cycle progression in cancer research models, both in vitro and in vivo.
Product Specifications
CAS Number
1957203-01-8
Product Name Alternative
Inhibitor, irreversible, inhibit, arrest, covalent, CDK, CDK7/Mat1/CycH, CDK7/Cyclin H/MAT1, CDK7, cell-cycle, Cyclin dependent kinase, YKL5124, YKL-5-124, YKL 5 124, Pol-II, T-loop, phosphorylation, transcription
Field of Research
Cell Biology
Purity
99.36% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.7 mM) ; DMSO:220 mg/mL (426.68 mM)
Smiles
CN (C) C[C@@H] (NC (=O) N1Cc2c (NC (=O) c3ccc (NC (=O) C=C) cc3) n[nH]c2C1 (C) C) c1ccccc1
Molecular Formula
C28H33N7O3
Molecular Weight
515.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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