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Tezacaftor

Tezacaftor (VX-661) is a CFTR corrector small molecule used in research to investigate cystic fibrosis therapies. It facilitates the cellular processing and trafficking of mutant CFTR proteins, with applications in both in vitro biochemical assays and in vivo preclinical models of CFTR dysfunction.

Product Specifications

CAS Number

1152311-62-0

Product Name Alternative

Inhibit, Inhibitor, Cystic fibrosis transmembrane conductance regulator, CFTR, Autophagy, Tezacaftor, VFTR, VX661, VX-661, VX 661

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

98.84% (May vary between batches)

Solubility

DMSO:245 mg/mL (470.7 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.61 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

CC (C) (CO) c1cc2cc (NC (=O) C3 (CC3) c3ccc4OC (F) (F) Oc4c3) c (F) cc2n1C[C@@H] (O) CO

Molecular Formula

C26H27F3N2O6

Molecular Weight

520.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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