PD 128042
PD 128042 (CI 976) is a potent, orally bioavailable small molecule that selectively inhibits ACAT (IC50: 73 nM) and Golgi-associated lysophospholipid acyltransferase (LPAT; IC50: 15 μM) . This dual activity disrupts intracellular lipid metabolism and membrane trafficking, making it a valuable research tool for studying atherosclerosis, lipid storage diseases, and vesicular transport in cellular models.
Product Specifications
CAS Number
114289-47-3
Product Name Alternative
CI976, CI-976, CI 976, Diglyceride acyltransferase, Diacylglycerol acyltransferase, ACAT, acyl-CoA:cholesterol acyltransferase, Acyltransferase, LPAT, inhibit, PD 128042, PD128042, PD-128042, oral, mono- acylglycerol acyltransferase, Inhibitor, endocytic membrane trafficking pathway, secretory, transferase
Field of Research
Metabolism Research
Purity
99.44% (May vary between batches)
Solubility
Ethanol:25 mg/mL (63.52 mM) ; DMF:25 mg/mL (63.52 mM) ; DMSO:25 mg/mL (63.52 mM)
Smiles
CCCCCCCCCCC (C) (C) C (=O) Nc1c (OC) cc (OC) cc1OC
Molecular Formula
C23H39NO4
Molecular Weight
393.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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