TLR3-IN-1
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor with an IC50 of 3.44 μM. It blocks dsRNA-induced TLR3 signaling and reduces pro-inflammatory cytokine production, such as TNF-α and IL-1β, in cellular models like RAW 264.7 macrophages, supporting its use in studying innate immunity and inflammatory diseases.
Product Specifications
CAS Number
1279713-77-7
Product Name Alternative
CU-CPT 4a, CU CPT 4a, Inhibitor, inhibit, IL-1β, TLR3 IN 1, TLR3/dsRNA complex, TLR3IN1, TLR-3-IN-1, TLR3-IN-1, TLR3, Toll-like Receptor (TLR), TNF-α, protein-RNA interaction
Field of Research
Cell Biology, Immunology & Inflammation
Purity
97.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.62 mM) ; DMSO:250 mg/mL (661.69 mM)
Smiles
OC (=O) [C@@H] (Cc1ccccc1) NC (=O) c1sc2cc (F) ccc2c1Cl
Molecular Formula
C18H13ClFNO3S
Molecular Weight
377.82
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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