Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Regorafenib (Standard)

Regorafenib (Standard) is the analytical standard of Regorafenib. This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity[1].

Product Specifications

CAS Number

755037-03-7

Product Name Alternative

BAY 73-4506 (Standard)

UNSPSC

12352005

Target

Autophagy; c-Kit; FGFR; PDGFR; Raf; Reference Standards; RET; Tie; VEGFR

Type

Reference Standards

Related Pathways

Autophagy; MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/regorafenib-standard.html

Smiles

O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F

Molecular Formula

C21H15ClF4N4O3

Molecular Weight

482.82

References & Citations

[1]Wilhelm SM, et al. Regorafenib (BAY 73-4506) : a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129 (1), 245-255.|[2]Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2 (1), 39-49.|[3]Carr BI, et al. Fluoro-Bay 43-9006 (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228 (2), 292-297.|[4]Wagner J, et al. Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. J Exp Clin Cancer Res. 2018 Jan 22;37 (1) :11.|[5]Matsuoka K, et al. Effective Sequential Combined Chemotherapy with Tipiracil and Regorafenib in Human Colorectal Cancer Cells. Int J Mol Sci. 2018 Sep 25;19 (10) . pii: E2915.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Mouse L-Phenylalanine ammonla-lyase, PAL ELISA Kit
YLA0960MO-01 48 Tests

Mouse L-Phenylalanine ammonla-lyase, PAL ELISA Kit

Sign In for Pricing
View Details
Mouse L-Phenylalanine ammonla-lyase, PAL ELISA Kit
YLA0960MO-02 96 Tests

Mouse L-Phenylalanine ammonla-lyase, PAL ELISA Kit

Sign In for Pricing
View Details
CSK Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV660858 1.0 µg DNA

CSK Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

Sign In for Pricing
View Details
Anti-TMED2 Antibody Picoband® Fluoro594 Conjugated
A09445-Fluoro594 100 µg/Vial

Anti-TMED2 Antibody Picoband® Fluoro594 Conjugated

Sign In for Pricing
View Details
SUN1 (NM_025154) Human Tagged Lenti ORF Clone
RC224605L4 10 µg

SUN1 (NM_025154) Human Tagged Lenti ORF Clone

Sign In for Pricing
View Details
Trp63 Recombinant Protein (Mouse)
RP181472 100 µg

Trp63 Recombinant Protein (Mouse)

Sign In for Pricing
View Details