MMAF
MonoMethyl auristatin F (MMAF) is a potent antimitotic agent that disrupts microtubule dynamics by inhibiting tubulin polymerization, thereby arresting cell division. This mechanism makes it a valuable payload in antibody-drug conjugates (ADCs) for cancer research, with applications in both in vitro cytotoxicity assays and in vivo xenograft studies.
Product Specifications
CAS Number
745017-94-1
Product Name Alternative
ADC Payload, ADCCytotoxin, ADC Cytotoxin, Cytotoxicity (Karpas 299 cell), Inhibitor, MonoMethyl auristatin F, Monomethylauristatin F, MMAF, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, inhibit
Field of Research
Signal Transduction
Purity
97.00% (May vary between batches)
Solubility
DMSO:250 mg/mL (341.55 mM)
Smiles
CC[C@H] (C) C ([C@@H] (CC (=O) N1CCC[C@H]1[C@H] (OC) [C@@H] (C) C (=O) N[C@@H] (Cc1ccccc1) C (O) =O) OC) N (C) C (=O) [C@@H] (NC (=O) [C@@H] (NC) C (C) C) C (C) C
Molecular Formula
C39H65N5O8
Molecular Weight
731.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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