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S49076

S49076 is a novel small molecule inhibitor targeting receptor tyrosine kinases MET, AXL/MER, and FGFR1/2/3. It effectively blocks their cellular phosphorylation and has demonstrated activity in preclinical in vitro and in vivo cancer models, supporting its use in oncology research.

Product Specifications

CAS Number

1265965-22-7

Product Name Alternative

Inhibit, Mer, Met, Fibroblast growth factor receptor, FGFR, FGFR3, FGFR2, Inhibitor, HGFR, c-Met/HGFR, c-Met, cMet/HGFR, cMet, AXL, S49076, S-49076, S 49076, TAMReceptor, TAM Receptor

Field of Research

Cardiovascular Research, Signal Transduction

Purity

91.88% (May vary between batches)

Solubility

DMSO:81 mg/mL (184.72 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.53 mM)

Smiles

O=C1CSC (=O) N1Cc1ccc2NC (=O) \C (=C/c3cc (CN4CCOCC4) c[nH]3) c2c1

Molecular Formula

C22H22N4O4S

Molecular Weight

438.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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