PF-06446846 (hydrochloride)
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9) . PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].
Product Specifications
CAS Number
[1632250-50-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pf-06446846-hydrochloride.html
Purity
99.44
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C1=NC=CC=C1Cl)[C@H]2CNCCC2)C3=CC=C(N4N=NC5=CC=CN=C54)C=C3.[H]Cl
Molecular Formula
C22H21Cl2N7O
Molecular Weight
470.35
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Available Sizes
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