PF-06446846 (hydrochloride)

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9) . PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].

Product Specifications

CAS Number

[1632250-50-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pf-06446846-hydrochloride.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C1=NC=CC=C1Cl)[C@H]2CNCCC2)C3=CC=C(N4N=NC5=CC=CN=C54)C=C3.[H]Cl

Molecular Formula

C22H21Cl2N7O

Molecular Weight

470.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15 (3) :e2001882.