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SZL P1-41

SZL P1-41 is a selective skp2 inhibitor that disrupts Skp2-SCF E3 ligase assembly and activity, blocking p27 and Akt ubiquitination in vitro and in vivo. It induces cell senescence, inhibits glycolysis, and demonstrates antitumor efficacy by suppressing the survival of cancer and cancer stem cells in various preclinical models.

Product Specifications

CAS Number

222716-34-9

Product Name Alternative

E1/E2/E3 Enzyme, E1 Enzyme, E2 conjugating enzyme, E1Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E1 activating enzyme, Apoptosis, E3Enzyme, E3 ligating enzyme, Inhibitor, inhibit, SZL P1 41, SZL P141, SZL P-1-41, SZL P1-41, skp2, Ubiquitin conjugating enzyme, Ubiquitin ligase, Ubiquitin activating enzyme

Field of Research

Cell Biology, Protein Biochemistry

Purity

99.60% (May vary between batches)

Solubility

DMSO:1.05 mg/mL (2.5 mM)

Smiles

CCc1cc2c (occ (-c3nc4ccccc4s3) c2=O) c (CN2CCCCC2) c1O

Molecular Formula

C24H24N2O3S

Molecular Weight

420.52

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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