SZL P1-41
SZL P1-41 is a selective skp2 inhibitor that disrupts Skp2-SCF E3 ligase assembly and activity, blocking p27 and Akt ubiquitination in vitro and in vivo. It induces cell senescence, inhibits glycolysis, and demonstrates antitumor efficacy by suppressing the survival of cancer and cancer stem cells in various preclinical models.
Product Specifications
CAS Number
222716-34-9
Product Name Alternative
E1/E2/E3 Enzyme, E1 Enzyme, E2 conjugating enzyme, E1Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E1 activating enzyme, Apoptosis, E3Enzyme, E3 ligating enzyme, Inhibitor, inhibit, SZL P1 41, SZL P141, SZL P-1-41, SZL P1-41, skp2, Ubiquitin conjugating enzyme, Ubiquitin ligase, Ubiquitin activating enzyme
Field of Research
Cell Biology, Protein Biochemistry
Purity
99.60% (May vary between batches)
Solubility
DMSO:1.05 mg/mL (2.5 mM)
Smiles
CCc1cc2c (occ (-c3nc4ccccc4s3) c2=O) c (CN2CCCCC2) c1O
Molecular Formula
C24H24N2O3S
Molecular Weight
420.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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