Jervine
Jervine is a steroidal alkaloid that acts as a potent inhibitor of the Smoothened (SMO) receptor, a key component of the Hedgehog signaling pathway. By binding to and inhibiting SMO, it prevents the activation of GLI transcription factors and downstream target genes. This mechanism makes it a valuable research tool for studying Hedgehog signaling in cancer, developmental biology, and in both cellular and animal models.
Product Specifications
CAS Number
469-59-0
Product Name Alternative
11-Ketocyclopamine
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Hedgehog inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 5 mg/ml), in DMF (up to 6 mg/ml), or in Ethanol (up to 20 mg/ml) .
Smiles
[H][C@@]12NC[C@@H] (C) C[C@H]1O[C@]1 (CC[C@]3 ([H]) C (C (=O) [C@@]4 ([H]) [C@@]3 ([H]) CC=C3C[C@@H] (O) CC[C@]43C) =C1C) [C@@H]2C
Molecular Formula
C27H39NO3
Molecular Weight
425.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(3β,23β) -17,23-Epoxy-3-hydroxyveratraman-11-one
Available Sizes
Frequently Asked Questions
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