NNK
NNK, a nitrosamine derived from nicotine, is a research chemical used to model lung carcinogenesis. It promotes proliferation and survival in human lung cancer cells by activating ERK1/2, PKCα, and key targets like Bcl-2 and c-Myc. This compound is widely employed in both in vitro studies and for establishing mouse models of lung cancer.
Product Specifications
CAS Number
64091-91-4
Product Name Alternative
Endogenous Metabolite, Cell proliferation, c-Myc, Bcl2, Nicotine-derived nitrosamine ketone, Nicotine-nitrosated derivative, NNK, Lung cancer, inhibit, Inhibitor, LOX, Phosphorylation
Field of Research
Metabolism Research
Purity
98.89% (May vary between batches)
Solubility
DMSO:247.5 mg/mL (1194.33 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:20 mg/mL (96.51 mM)
Smiles
CN (CCCC (=O) c1cccnc1) N=O
Molecular Formula
C10H13N3O2
Molecular Weight
207.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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