Purvalanol A
Purvalanol A (NG-60) is a potent, cell-permeable inhibitor of cyclin-dependent kinases (CDKs) . It demonstrates high selectivity with IC50 values of 70, 4, 35, and 850 nM for cdk2/cyclin A, B, E, and cdk4/cyclin D1, respectively. This compound is widely used in vitro to study cell cycle regulation, apoptosis, and oncogenesis.
Product Specifications
CAS Number
212844-53-6
Product Name Alternative
NG-60
Field of Research
Cell Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
CDK inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 35 mg/ml)
Smiles
CC (C) C (CO) Nc1nc (Nc2cccc (Cl) c2) c2ncn (C (C) C) c2n1
Molecular Formula
C19H25ClN6O
Molecular Weight
388.89
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(2R) -2-[[6-[ (3-Chlorophenyl) amino]-9- (1-methylethyl) -9H-purin-2-yl]amino]-3-methyl-1-butanol
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