Quizartinib
Quizartinib (AC220) is a potent and selective oral type II FLT3 inhibitor, effective against both FLT3-WT and FLT3-ITD mutations. It induces apoptosis in leukemic cells and has demonstrated significant anti-tumor activity in preclinical models of acute myeloid leukemia (AML), supporting its investigation in both in vitro and in vivo research.
Product Specifications
CAS Number
950769-58-1
Product Name Alternative
AC220
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
>98%
Bioactivity
Selective FLT3 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
CC (C) (C) c1cc (NC (=O) Nc2ccc (cc2) -c2cn3c (n2) sc2cc (OCCN4CCOCC4) ccc32) no1
Molecular Formula
C29H32N6O4S
Molecular Weight
560.67
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1- (5- (t-Butyl) isoxazol-3-yl) -3- (4- (7- (2-morpholinoethoxy) benzo[d]imidazo[2,1-b]thiazol-2-yl) phenyl) urea
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