Adavosertib (MK-1775)
Adavosertib (MK-1775) is a potent and selective Wee1 kinase inhibitor (IC50=5.2 nM) that induces cell cycle arrest and inhibits proliferation. It is widely used in cancer research, particularly in studies of DNA damage response, and has demonstrated antitumor efficacy in both in vitro and in vivo models.
Product Specifications
CAS Number
955365-80-7
Product Name Alternative
MK-1775; AZD 1775
Field of Research
Cancer Biology, Cell Biology, Immunology & Inflammation, Protein Biochemistry
Purity
>98%
Bioactivity
Wee1 checkpoint kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (70 mg/ml)
Smiles
C (C=C) N1N (C=2C (C1=O) =CN=C (NC3=CC=C (C=C3) N4CCN (C) CC4) N2) C=5N=C (C (C) (C) O) C=CC5
Molecular Formula
C27H32N8O2
Molecular Weight
500.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1,2-Dihydro-1-[6- (1-hydroxy-1-methylethyl) -2-pyridinyl]-6-[[4- (4-methyl-1-piperazinyl) -phenyl]amino]-2- (2-propen-1-yl) -3H-pyrazolo[3,4-d]pyrimidin-3-one
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