LCL161
LCL161 is an orally active SMAC mimetic and IAP antagonist, potently inhibiting cIAP1 (IC50=0.4 nM) and XIAP (IC50=35 nM) . It demonstrates potential antitumor activity and has been utilized in preclinical research, including in vitro studies in cancer cell lines and in vivo models evaluating its efficacy against various tumors.
Product Specifications
CAS Number
1005342-46-0
Product Name Alternative
CIAP, LCL 161, LCL161, LCL-161, IAP, Inhibitor, inhibit
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:93 mg/mL (185.77 mM) ; Ethanol:16 mg/mL (31.96 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
C ([C@@H] (NC ([C@@H] (NC) C) =O) [C@H]1CCCCC1) (=O) N2[C@@H] (CCC2) C3=NC (C (=O) C4=CC=C (F) C=C4) =CS3
Molecular Formula
C26H33FN4O3S
Molecular Weight
500.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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