AF-353
AF-353 (Ro-4) is a potent, orally bioavailable P2X3 and P2X2/3 receptor antagonist, exhibiting high affinity for human and rat P2X3 receptors (pIC50=8.0) . This compound is a valuable research tool for investigating the role of these receptors in pain, cough, and inflammation in both in vitro and in vivo models.
Product Specifications
CAS Number
865305-30-2
Product Name Alternative
AF353, AF-353, AF 353, inhibit, Inhibitor, P2X Receptor, P2X3, P2XRs, P2XReceptor, Ro4, Ro-4, Ro 4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
92.98% (May vary between batches)
Solubility
DMSO:55 mg/mL (137.43 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM)
Smiles
COc1cc (C (C) C) c (Oc2cnc (N) nc2N) cc1I
Molecular Formula
C14H17IN4O2
Molecular Weight
400.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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