AF-353
AF-353 (Ro-4) is a potent, orally bioavailable P2X3 and P2X2/3 receptor antagonist, exhibiting high affinity for human and rat P2X3 receptors (pIC50=8.0) . This compound is a valuable research tool for investigating the role of these receptors in pain, cough, and inflammation in both in vitro and in vivo models.
Product Specifications
CAS Number
865305-30-2
Product Name Alternative
AF353, AF-353, AF 353, inhibit, Inhibitor, P2X Receptor, P2X3, P2XRs, P2XReceptor, Ro4, Ro-4, Ro 4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
92.98% (May vary between batches)
Solubility
DMSO:55 mg/mL (137.43 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM)
Smiles
COc1cc (C (C) C) c (Oc2cnc (N) nc2N) cc1I
Molecular Formula
C14H17IN4O2
Molecular Weight
400.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6381317-01 0.1 mL
HLA-DRB5 (HLA Class II Histocompatibility Antigen, DR beta 5 Chain, DR beta-5, DR2-beta-2, Dw2, MHC Class II Antigen DRB5) (MaxLight 650)
Sign In for Pricing
View Details MBS6381317-02 5x 0.1 mL
HLA-DRB5 (HLA Class II Histocompatibility Antigen, DR beta 5 Chain, DR beta-5, DR2-beta-2, Dw2, MHC Class II Antigen DRB5) (MaxLight 650)
Sign In for Pricing
View Details 
KLM2537 96 Well
Mouse Tumor necrosis Factor Receptor superfamily member 11A, TNFRSF11A) GENLISA ELISA
Sign In for Pricing
View Details orb2875016 100 µL
Phospho-NFKB1 (Ser373) Rabbit pAb, Pacific Blue conjugated
Sign In for Pricing
View Details 
RC227093L4V 200 µL
RAB7L1 (RAB29) (NM_001135662) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details