Lexibulin
Lexibulin (CYT-997) is a potent small-molecule tubulin polymerization inhibitor (IC50: 10-100 nM) that induces G2/M cell cycle arrest by disrupting mitotic spindle formation. This mechanism has demonstrated antitumor activity in both cellular assays and in vivo models, supporting its research application in oncology and vascular disruption.
Product Specifications
CAS Number
917111-44-5
Product Name Alternative
Inhibit, MicrotubuleAssociated, Microtubule Associated, Microtubule/Tubulin, microtubule, Inhibitor, Lexibulin, CYT 997, CYT997, CYT-997, Apoptosis, ReactiveOxygenSpecies, Reactive Oxygen Species
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Purity
98.87% (May vary between batches)
Solubility
Ethanol:16 mg/mL (36.82 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.59 mM) ; DMSO:80 mg/mL (184.11 mM)
Smiles
CCC[C@H] (Nc1nc (ncc1C) -c1ccc (NC (=O) NCC) c (OC) c1) c1cccnc1
Molecular Formula
C24H30N6O2
Molecular Weight
434.53
Storage Conditions
-20°C
Notes
For research use only.
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